[proofplan]
We compute the conditional density by dividing the joint Gaussian density of $(X_1,X_2)$ by the marginal density of $X_2$. The main algebraic step is the Schur-complement factorization of $\Sigma$, which gives both the determinant identity and the completed-square form of the quadratic exponent. Once the joint density separates into a normal density in $x_1$ times a normal density in $x_2$, the quotient is exactly the stated multivariate normal density.
[/proofplan]
[step:Show that the Schur complement is positive definite]
Since $\Sigma$ is symmetric positive definite, the principal block $\Sigma_{22}$ is symmetric positive definite. Indeed, for every nonzero vector $v \in \mathbb{R}^{p_2}$,
\begin{align*}
v^\top \Sigma_{22} v
=
\begin{pmatrix} 0 \\ v \end{pmatrix}^{\top}
\Sigma
\begin{pmatrix} 0 \\ v \end{pmatrix}
>0.
\end{align*}
Thus $\Sigma_{22}$ is invertible.
Define the Schur complement matrix $S \in \mathbb{R}^{p_1\times p_1}$ by
\begin{align*}
S := \Sigma_{11}-\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}.
\end{align*}
For any nonzero vector $u \in \mathbb{R}^{p_1}$, define
\begin{align*}
v := -\Sigma_{22}^{-1}\Sigma_{21}u \in \mathbb{R}^{p_2}.
\end{align*}
Then
\begin{align*}
\begin{pmatrix} u \\ v \end{pmatrix}^{\top}
\Sigma
\begin{pmatrix} u \\ v \end{pmatrix}
&=
u^\top \Sigma_{11}u+u^\top\Sigma_{12}v+v^\top\Sigma_{21}u+v^\top\Sigma_{22}v \\
&=
u^\top \Sigma_{11}u-u^\top\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}u
-u^\top\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}u
+u^\top\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}u \\
&=
u^\top S u.
\end{align*}
Since $u \neq 0$, the vector $\begin{pmatrix}u\\v\end{pmatrix}$ is nonzero, so positive definiteness of $\Sigma$ gives $u^\top S u>0$. Therefore $S=\Sigma_{1\mid 2}$ is symmetric positive definite.
[guided]
The conditional covariance matrix is the Schur complement of $\Sigma_{22}$ in $\Sigma$, so we first verify that it is a legitimate covariance matrix.
Because $\Sigma$ is symmetric positive definite, every principal covariance block is positive definite. For $v \in \mathbb{R}^{p_2}$ with $v \neq 0$, insert $v$ into the second block and zero into the first block:
\begin{align*}
v^\top \Sigma_{22}v
=
\begin{pmatrix}0\\v\end{pmatrix}^{\top}
\Sigma
\begin{pmatrix}0\\v\end{pmatrix}
>0.
\end{align*}
Hence $\Sigma_{22}$ is symmetric positive definite and therefore invertible.
Now define
\begin{align*}
S := \Sigma_{11}-\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}.
\end{align*}
To prove that $S$ is positive definite, fix a nonzero vector $u \in \mathbb{R}^{p_1}$. The correct second block to pair with $u$ is the value that cancels the mixed terms, namely
\begin{align*}
v := -\Sigma_{22}^{-1}\Sigma_{21}u.
\end{align*}
Substituting the vector $\begin{pmatrix}u\\v\end{pmatrix}$ into the quadratic form of $\Sigma$ gives
\begin{align*}
\begin{pmatrix} u \\ v \end{pmatrix}^{\top}
\Sigma
\begin{pmatrix} u \\ v \end{pmatrix}
&=
u^\top \Sigma_{11}u+u^\top\Sigma_{12}v+v^\top\Sigma_{21}u+v^\top\Sigma_{22}v \\
&=
u^\top \Sigma_{11}u-u^\top\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}u
-u^\top\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}u
+u^\top\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}u \\
&=
u^\top S u.
\end{align*}
The vector $\begin{pmatrix}u\\v\end{pmatrix}$ is nonzero because its first block is $u \neq 0$. Since $\Sigma$ is positive definite, the left-hand side is strictly positive. Hence $u^\top S u>0$ for every nonzero $u \in \mathbb{R}^{p_1}$, which proves that $S=\Sigma_{1\mid 2}$ is positive definite.
[/guided]
[/step]
[step:Factor the covariance matrix and compute its determinant]
Define the matrix $A \in \mathbb{R}^{p_1\times p_2}$ by
\begin{align*}
A := \Sigma_{12}\Sigma_{22}^{-1}.
\end{align*}
Since $\Sigma$ is symmetric, $\Sigma_{21}=\Sigma_{12}^\top$; since $\Sigma_{22}$ is symmetric positive definite, $\Sigma_{22}^{-1}$ is symmetric. Hence
\begin{align*}
A^\top = \Sigma_{22}^{-1}\Sigma_{21}.
\end{align*}
Then
\begin{align*}
\Sigma
&=
\begin{pmatrix}
I_{p_1} & A \\
0 & I_{p_2}
\end{pmatrix}
\begin{pmatrix}
S & 0 \\
0 & \Sigma_{22}
\end{pmatrix}
\begin{pmatrix}
I_{p_1} & 0 \\
A^\top & I_{p_2}
\end{pmatrix}.
\end{align*}
Taking determinants and using that both triangular factors have determinant $1$, we get
\begin{align*}
\det \Sigma = \det S \, \det \Sigma_{22}.
\end{align*}
[/step]
[step:Complete the square in the joint Gaussian density]
For $m \in \{p,p_1,p_2\}$, let $\mathcal{L}^m$ denote $m$-dimensional Lebesgue measure on $\mathbb{R}^m$. Let $f_X: \mathbb{R}^{p} \to [0,\infty)$ be the density of $X$ with respect to $\mathcal{L}^{p}$. For $x_1 \in \mathbb{R}^{p_1}$ and $x_2 \in \mathbb{R}^{p_2}$, define
\begin{align*}
y_1 &:= x_1-\mu_1, \\
y_2 &:= x_2-\mu_2.
\end{align*}
Using the factorization of $\Sigma$ from the previous step, the inverse quadratic form is
\begin{align*}
\begin{pmatrix} y_1 \\ y_2 \end{pmatrix}^{\top}
\Sigma^{-1}
\begin{pmatrix} y_1 \\ y_2 \end{pmatrix}
=
(y_1-Ay_2)^\top S^{-1}(y_1-Ay_2)+y_2^\top\Sigma_{22}^{-1}y_2.
\end{align*}
Therefore the joint density is
\begin{align*}
f_X(x_1,x_2)
&=
\frac{1}{(2\pi)^{p/2}(\det\Sigma)^{1/2}}
\exp\left(
-\frac{1}{2}
\begin{pmatrix} y_1 \\ y_2 \end{pmatrix}^{\top}
\Sigma^{-1}
\begin{pmatrix} y_1 \\ y_2 \end{pmatrix}
\right) \\
&=
\frac{1}{(2\pi)^{p_1/2}(\det S)^{1/2}}
\exp\left(
-\frac{1}{2}(x_1-\mu_1-A(x_2-\mu_2))^\top S^{-1}
(x_1-\mu_1-A(x_2-\mu_2))
\right) \\
&\qquad\cdot
\frac{1}{(2\pi)^{p_2/2}(\det\Sigma_{22})^{1/2}}
\exp\left(
-\frac{1}{2}(x_2-\mu_2)^\top\Sigma_{22}^{-1}(x_2-\mu_2)
\right).
\end{align*}
[guided]
The goal is to isolate all dependence on $x_1$ into one Gaussian density. Define
\begin{align*}
y_1 &:= x_1-\mu_1, \\
y_2 &:= x_2-\mu_2,
\end{align*}
so that the exponent in the joint density is the quadratic form
\begin{align*}
\begin{pmatrix} y_1 \\ y_2 \end{pmatrix}^{\top}
\Sigma^{-1}
\begin{pmatrix} y_1 \\ y_2 \end{pmatrix}.
\end{align*}
The factorization
\begin{align*}
\Sigma
&=
\begin{pmatrix}
I_{p_1} & A \\
0 & I_{p_2}
\end{pmatrix}
\begin{pmatrix}
S & 0 \\
0 & \Sigma_{22}
\end{pmatrix}
\begin{pmatrix}
I_{p_1} & 0 \\
A^\top & I_{p_2}
\end{pmatrix}
\end{align*}
gives an explicit inverse by inverting the three factors in reverse order:
\begin{align*}
\Sigma^{-1}
&=
\begin{pmatrix}
I_{p_1} & 0 \\
-A^\top & I_{p_2}
\end{pmatrix}
\begin{pmatrix}
S^{-1} & 0 \\
0 & \Sigma_{22}^{-1}
\end{pmatrix}
\begin{pmatrix}
I_{p_1} & -A \\
0 & I_{p_2}
\end{pmatrix}.
\end{align*}
The rightmost factor sends $\begin{pmatrix}y_1\\y_2\end{pmatrix}$ to $\begin{pmatrix}y_1-Ay_2\\y_2\end{pmatrix}$. Therefore the quadratic form becomes
\begin{align*}
\begin{pmatrix} y_1 \\ y_2 \end{pmatrix}^{\top}
\Sigma^{-1}
\begin{pmatrix} y_1 \\ y_2 \end{pmatrix}
=
(y_1-Ay_2)^\top S^{-1}(y_1-Ay_2)+y_2^\top\Sigma_{22}^{-1}y_2.
\end{align*}
This is the completion of the square: the first term is a quadratic form in
\begin{align*}
x_1-\mu_1-A(x_2-\mu_2),
\end{align*}
and the second term depends only on $x_2$.
Using the determinant identity $\det\Sigma=\det S\,\det\Sigma_{22}$ and $p=p_1+p_2$, the normalizing constant also splits:
\begin{align*}
\frac{1}{(2\pi)^{p/2}(\det\Sigma)^{1/2}}
=
\frac{1}{(2\pi)^{p_1/2}(\det S)^{1/2}}
\frac{1}{(2\pi)^{p_2/2}(\det\Sigma_{22})^{1/2}}.
\end{align*}
Substituting the completed square and the split normalizing constant into the joint density gives
\begin{align*}
f_X(x_1,x_2)
&=
\frac{1}{(2\pi)^{p_1/2}(\det S)^{1/2}}
\exp\left(
-\frac{1}{2}(x_1-\mu_1-A(x_2-\mu_2))^\top S^{-1}
(x_1-\mu_1-A(x_2-\mu_2))
\right) \\
&\qquad\cdot
\frac{1}{(2\pi)^{p_2/2}(\det\Sigma_{22})^{1/2}}
\exp\left(
-\frac{1}{2}(x_2-\mu_2)^\top\Sigma_{22}^{-1}(x_2-\mu_2)
\right).
\end{align*}
[/guided]
[/step]
[step:Identify the marginal density of $X_2$]
Define $f_{X_2}: \mathbb{R}^{p_2} \to [0,\infty)$ by
\begin{align*}
f_{X_2}(x_2) := \int_{\mathbb{R}^{p_1}} f_X(x_1,x_2)\,d\mathcal{L}^{p_1}(x_1).
\end{align*}
From the product form above and the normalization of the $\mathcal{N}_{p_1}(\mu_1+A(x_2-\mu_2),S)$ density,
\begin{align*}
f_{X_2}(x_2)
=
\frac{1}{(2\pi)^{p_2/2}(\det\Sigma_{22})^{1/2}}
\exp\left(
-\frac{1}{2}(x_2-\mu_2)^\top\Sigma_{22}^{-1}(x_2-\mu_2)
\right).
\end{align*}
Thus $X_2 \sim \mathcal{N}_{p_2}(\mu_2,\Sigma_{22})$.
[/step]
[step:Divide the joint density by the marginal density]
For each fixed $x_2 \in \mathbb{R}^{p_2}$, the marginal density $f_{X_2}(x_2)$ is strictly positive. Define the map $q: \mathbb{R}^{p_1}\times\mathbb{R}^{p_2}\to[0,\infty)$ by
\begin{align*}
q(x_1,x_2)
:=
\frac{f_X(x_1,x_2)}{f_{X_2}(x_2)}.
\end{align*}
This quotient defines a regular conditional density of $X_1$ given $X_2$. Indeed, for every Borel set $B \subset \mathbb{R}^{p_1}$ and every Borel set $C \subset \mathbb{R}^{p_2}$, Tonelli's theorem applies because the integrand is non-negative, and the definition of $f_{X_2}$ gives
\begin{align*}
\mathbb{P}(X_1\in B, X_2\in C)
&=
\int_C \int_B f_X(x_1,x_2)\,d\mathcal{L}^{p_1}(x_1)\,d\mathcal{L}^{p_2}(x_2) \\
&=
\int_C \int_B q(x_1,x_2)\,d\mathcal{L}^{p_1}(x_1)\, f_{X_2}(x_2)\,d\mathcal{L}^{p_2}(x_2).
\end{align*}
Thus the probability measure $B\mapsto \int_B q(x_1,x_2)\,d\mathcal{L}^{p_1}(x_1)$ is a version of the conditional law of $X_1$ given $X_2=x_2$. Using the product decomposition of $f_X$ and the formula for $f_{X_2}$, the factors depending only on $x_2$ cancel, leaving
\begin{align*}
q(x_1,x_2)
=
\frac{1}{(2\pi)^{p_1/2}(\det S)^{1/2}}
\exp\left(
-\frac{1}{2}(x_1-\mu_1-A(x_2-\mu_2))^\top S^{-1}
(x_1-\mu_1-A(x_2-\mu_2))
\right).
\end{align*}
Since $A=\Sigma_{12}\Sigma_{22}^{-1}$ and $S=\Sigma_{11}-\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}$, this is the density of
\begin{align*}
\mathcal{N}_{p_1}\left(
\mu_1+\Sigma_{12}\Sigma_{22}^{-1}(x_2-\mu_2),
\Sigma_{11}-\Sigma_{12}\Sigma_{22}^{-1}\Sigma_{21}
\right).
\end{align*}
Therefore, for every $x_2 \in \mathbb{R}^{p_2}$,
\begin{align*}
X_1 \mid X_2=x_2 \sim \mathcal{N}_{p_1}(\mu_{1\mid 2}(x_2),\Sigma_{1\mid 2}),
\end{align*}
as claimed.
[/step]