[guided]The strategy is to derive a contradiction from the assumption that $S_n$ is soluble, by showing this would force the alternating group $A_n$ to be soluble — which is impossible because $A_n$ is simple and non-abelian.
**Why does solubility of $S_n$ imply solubility of $A_n$?** The [Persistence of Solubility](/theorems/1285) states two closure properties: (1) every subgroup of a soluble group is soluble, and (2) every quotient of a soluble group is soluble. Since $A_n \leq S_n$ (the alternating group is a subgroup of index $2$ in the symmetric group), property (1) gives us solubility of $A_n$ for free, assuming $S_n$ is soluble. This is the key reduction.
**Why can a simple non-abelian group not be soluble?** Recall that a group $G$ is soluble if and only if it has a composition series
\begin{align*}
\{e\} = G_r \trianglelefteq G_{r-1} \trianglelefteq \cdots \trianglelefteq G_0 = G
\end{align*}
in which every successive quotient $G_i / G_{i+1}$ is abelian. If $G$ is simple (no normal subgroups other than $\{e\}$ and $G$), then the only composition series is $\{e\} \trianglelefteq G$, and the sole quotient $G/\{e\} \cong G$ must be abelian for solubility. Therefore a simple group is soluble if and only if it is abelian (equivalently, cyclic of prime order). Since $A_n$ is non-abelian for $n \geq 5$ — for instance, the $3$-cycles $(1\,2\,3)$ and $(1\,2\,4)$ in $A_5$ do not commute:
\begin{align*}
(1\,2\,3)(1\,2\,4) &= (1\,3)(2\,4), \\
(1\,2\,4)(1\,2\,3) &= (1\,4)(2\,3),
\end{align*}
and $(1\,3)(2\,4) \neq (1\,4)(2\,3)$ — the group $A_n$ is simple but not abelian. Therefore $A_n$ is not soluble.
**Why does the argument fail for $n \leq 4$?** The theorem [$A_n$ is Simple for $n \geq 5$](/theorems/1286) requires $n \geq 5$. For smaller values: $A_1$ and $A_2$ are trivial, $A_3 \cong \mathbb{Z}/3\mathbb{Z}$ is cyclic (hence soluble), and $A_4$ has the normal subgroup $V_4 = \{e, (1\,2)(3\,4), (1\,3)(2\,4), (1\,4)(2\,3)\}$ (the Klein four-group), yielding the composition series $\{e\} \trianglelefteq V_4 \trianglelefteq A_4$ with abelian quotients. Correspondingly, $S_4$ is soluble, and the general quartic is indeed soluble by radicals (via Ferrari's method).[/guided]