[guided]The extended Metropolis-Hastings algorithm is only meaningful if the proposed extended target is a genuine probability measure. The nonnegativity assumption is exactly what ensures that $\widehat\gamma$ can be used as an unnormalized density. Since $\widehat\gamma:X\times S\to[0,\infty)$ is measurable, the set function
\begin{align*}
B\mapsto \int_B\widehat\gamma(x,u)\,d(\lambda\otimes\rho)(x,u)
\end{align*}
is a measure on $(X\times S,\mathcal A\otimes\mathcal S)$.
We must compute its total mass. Because $\widehat\gamma$ is nonnegative, Tonelli's theorem applies without any prior integrability assumption once the measure-space hypotheses are checked. The space $(X,\mathcal A,\lambda)$ is sigma-finite by hypothesis, and $(S,\mathcal S,\rho)$ is sigma-finite because $\rho(S)=1$. Therefore Tonelli's theorem gives
\begin{align*}
\int_{X\times S}\widehat\gamma(x,u)\,d(\lambda\otimes\rho)(x,u)=\int_X\left(\int_S\widehat\gamma(x,u)\,d\rho(u)\right)d\lambda(x).
\end{align*}
The inner integral is exactly the expectation of the estimator at fixed $x$, taken with respect to the auxiliary law $\rho$. The unbiasedness hypothesis states that this inner integral equals $\gamma(x)$ for every $x\in X$. Therefore
\begin{align*}
\int_{X\times S}\widehat\gamma(x,u)\,d(\lambda\otimes\rho)(x,u)=\int_X\gamma(x)\,d\lambda(x)=Z.
\end{align*}
The assumption $0<Z<\infty$ now gives both finiteness and nonzero total mass, so division by $Z$ normalizes the extended measure. Hence $\widetilde\pi$ is a probability measure.[/guided]